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KMID : 0545120120220010080
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 1 p.80 ~ p.83
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New Production of 5-Bromotoluhydroquinone and 4-O-Methyltoluhydroquinone from the Marine-Derived Fungus Dothideomycete sp.
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Alain S. Leutou
Yun Keum-Ja
Choi Hong-Dae
Kang Jung-Sook
Son Byeng-Wha
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Abstract
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The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5- bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures of 1 and 2 were assigned through the spectroscopic data analyses. Compounds 1-4 showed a potent antibacterial activity against the methicillinresistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 6.2, 12.5, 6.2, and 12.5 μg/ml, respectively. Compounds 1-4 also exhibited a moderate radical scavenging activity against 1,1-diphenyl-2- picrylhydrazyl (DPPH) with IC50 values of 11.0, 17.0, 12.0, and 7.0 μM, respectively, which were more active than the positive control, L-ascorbic acid (IC50, 20.0 μM).
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KEYWORD
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5-Bromotoluhydroquinone, 4-O-methyltoluhydroquinone, toluhydroquinone, gentisyl alcohol, Dothideomycete sp.
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